- SynonymCSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
- SourceRabbit M-CSF R, His Tag (CSR-R82H5) is expressed from human 293 cells (HEK293). It contains AA Val 20 - Ser 503 (Accession # G1TTE0-1).Predicted N-terminus: Val 20Request for sequence
- Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.2 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- EndotoxinLess than 1.0 EU per μg by the LAL method.
- Purity
>90% as determined by SDS-PAGE.
- Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
- Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
- Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Rabbit M-CSF R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
- BackgroundColony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer"s disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
- References
- (1)Ridge, et al., 1990, Proc Natl Acad Sci U S A., 87(4): 1377-80.
- (2)Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17): 4442–51.
- (3)Tamimi, R. M., 2008, Cancer Research 68 (1): 18–21.
- (4)Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20): 9312–6.
- (5)Sapi, Eva, 2004, Experimental Biology and Medicine 229 (1): 1–11.
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.
AcroBiosystems是专注于生物药开发过程的蛋白技术和产品的全球化品牌，目前位于美国特拉华州的纽瓦克市，是一家专业研发、生产、销售蛋白相关分子生物学试剂的高科技公司。AcroBiosystems从成立之初至今一直致力于提供在药物研发过程中所需的高质量的靶点蛋白，满足市场对大批量、高批间*性的蛋白试剂的需求，产品和服务面向全球制药公司、生物技术公司及科研院所。产品包括免疫检查点蛋白、生物素标记蛋白、Fc受体蛋白、CAR-T靶点蛋白等，基于AviTagTM标记技术和化学标记技术的生物素标记蛋白系列被广泛应用于Biacore，AlphaLisa，MSD等平台。这些产品受到了学术界的*好评。
CD Feed X Supplement Plus, Liquid No.CF-1116
产品介绍
品牌：acrobiosystems
规格：500ml
产品描述：CD细胞的生长的补充液是化学定义的，能显著提高细胞密度和延长细胞活力，从而增加靶蛋白的表达，使用剂量为5-10%（V/V）。与CD 293 TGE培养基配合使用，BPM-BPfectin和293-Expression MAX-1可提高蛋白表达量。
产品特性：① 显著提高生产率
② 无动物源、无蛋白质、无血清和化学成分
储存条件：2℃-8℃，避光。
产品参数：
部分产品的详细列表：AcroBiosystems授权代理
货号 | 产品 | 规格 | 价格（美元） |
BAF-HF268 | FITC-Labeled Human BAFF / TNFSF13B / CD257 Protein, Fc Tag | 25ug | $290 |
BCA-HF254 | FITC-Labeled Human BCMA, Fc Tag | 25ug | $290 |
BCA-HF2H1 | FITC-Labeled Human BCMA, His Tag | 25ug | $290 |
![ACROBiosystems/Influenza A[A/swine/Jiangsu/J004/2018(H1N1)] Hemagglutinin (HA) Protein, His Tag/1mg/HEN](images/no_picture.gif)
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